Creatinine clearance (CrCl) for renal drug dose adjustment. Not the same as eGFR.
📋 Source: Cockcroft-Gault equation (Cockcroft & Gault, Nephron 1976). Kidney Health Australia — eGFR. Used for drug dosing adjustments — not interchangeable with CKD-EPI eGFR for CKD staging. Your doctor or healthcare provider knows your history and circumstances — always follow their personalised advice over general information.
Use this for drug dosing. Most product information bases renal dose adjustments on Cockcroft-Gault CrCl, not CKD-EPI eGFR. The two can differ significantly.
CrCl (actual weight)
mL/min
CrCl (adjusted weight)
mL/min
Common drugs requiring renal adjustment
DOACs: Rivaroxaban — avoid if CrCl <15. Apixaban — reduce dose if CrCl 25–30 (with other criteria). Dabigatran — reduce dose if CrCl 30–50, avoid if <30.
Metformin: Reduce dose if CrCl 30–60. Avoid if CrCl <30.
Digoxin: Reduce dose if CrCl <60. Monitor levels.
Lithium: Reduce dose and increase monitoring if CrCl <60.
Antibiotics: Gentamicin, vancomycin, trimethoprim, nitrofurantoin (avoid if CrCl <30), cefalexin — all require renal adjustment.
Always check the AMH or product information for specific drug dosing thresholds.