Calculates total oral morphine equivalent daily dose using FPM ANZCA PS01(PM) Appendix 2 (October 2025) conversion factors, with Take Home Naloxone guidance auto-surfaced from the same source. Browser-only, nothing leaves your device.
📋 Source:Faculty of Pain Medicine, ANZCA — PS01(PM) Appendix 2 (October 2025 update): conversion factors and THN thresholds reproduced verbatim with full attribution. PDF of source table. Companion statement: PS01(PM) statement on opioids in CNCP (2025). The official mobile app (with the same data) is available at the FPM ANZCA Opioid Calculator page (iOS & Android). Conversion factors verified June 2026 against the Oct 2025 update.
This calculator is a reference aid for registered medical professionals. Opioid prescribing remains the clinical responsibility of the prescriber, made against the current TGA Product Information and the patient's clinical context. Equianalgesic tables are not switching protocols — see "Practical considerations" above.
Reference for clinicians. This is a calculation aid, not a switching protocol. Equianalgesic tables are intended for comparison of opioids — using them directly to substitute one for another can lead to overdose. Always individualise for the patient, current TGA Product Information, renal/hepatic function, age, frailty, co-prescribed sedatives, and the regulatory requirements of your state. Specialist input recommended for any complex switch.
From the source document — keep these in mind:
1. The table is for comparison of opioids/formulations within a patient or cohort — not a switching protocol. 2. Considerable pharmacokinetic and pharmacodynamic variability within and between individuals. 3. Modified-release and immediate-release preparations must both be added to the oMEDD when used together. 4.Methadone, fentanyl lozenges and neuraxial opioids are excluded from this table (complex pharmacokinetics) — specialist consultation required for any of these. 5. The literature suggests "there is no safe dose of opioid" — THN should be considered with every opioid prescription based on individual risk.
Current opioid regimen
Add one row per opioid/formulation. Both MR and IR doses count — add each separately.
Outside this calculator — refer or specialist input
PS01(PM) Appendix 2 explicitly excludes the following due to complex, variable pharmacokinetics. Do not extrapolate from the conversion factors above:
Take Home Naloxone — FPM ANZCA 2025 guidance
Out-patient opioid prescribing:
oMEDD 1–40 mg:Consider THN and patient education, adjusted for individual risk.
oMEDD > 40 mg:Recommend THN and patient education, adjusted for individual risk.
Risk factors that raise the priority for THN (non-linear effect):
Disordered sleep, mental health disorder, palliative care
Child < 18 in household (accidental ingestion risk)
oMEDD > 40 mg is associated with ~4× increased cardiorespiratory event risk; oMEDD > 100 mg ~11×. Co-prescription of benzodiazepines, gabapentinoids or alcohol use makes risk non-linear (PS01(PM) 2025, citing Franklin 2014).