Anion gap calculations are approximations. Clinical interpretation requires the full clinical context including history, arterial blood gas, and other electrolytes. Always correlate with the patient's clinical status.

Sources

  1. Emmett M, Narins RG. Clinical use of the anion gap. Medicine. 1977;56(1):38–54.
  2. Figge J, Jabor A, Kazda A, Fencl V. Anion gap and hypoalbuminemia. Critical Care Medicine. 1998;26(11):1807–1810. doi:10.1097/00003246-199811000-00019
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